Eicosatetraenoic acid (ETA) designates any straight chain tetra-unsaturated 20-carbon fatty acid. The pure compounds, which are rarely encountered, are colorless oils. Two isomers, both of them essential fatty acids, are of particular interest:
- all-cis-5,8,11,14-eicosatetraenoic acid is an ω-6 fatty acid with the trivial name arachidonic acid. It is formed by a desaturation of dihomo-gamma-linolenic acid (DGLA, 20:3 ω-6).
- all-cis-8,11,14,17-eicosatetraenoic acid is an ω-3 fatty acid. It is an intermediate between stearidonic acid (18:4 ω-3) and eicosapentaenoic acid (EPA, 20:5 ω-3)
Some chemistry sources define 'arachadonic acid' to designate any of the eicosatetraenoic acids. However, almost all writings in biology, medicine, and nutrition limit the use of the term 'arachidonic acid' to all-cis-5,8,11,14-eicosatetraenoic acid (ω-6).
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Transcription
Precursors to eicosanoids
Eicosanoids, a diverse family of signaling molecules, are produced by oxygenation of polyunsaturated eicosatetraenoic acids. The eicosanoids, working in tandem, contribute to a lipid signaling complex widely responsible for inducing an inflammatory immune response.[1] Common signs of inflammation are both internal and external, with effects like visible redness, pain in the surrounding area, swelling, and the sensation of heat—many of these an effect of varying eicosanoid species.[2] These effects are associated with and have been observed in patients with cancers and various neurological/metabolic disorders.[3]
Related studies
ETA is found in green-lipped mussel and appears to inhibit the oxygenation of arachidonic acid by both the cyclooxygenase (COX) and lipoxygenase pathways.[4]
Mutant of Mortierella alpina 1S-4 is a fungus employed for producing arachidonic acid. These mutants produce larger amounts of ETA due to the expression of an ω-3-desaturase gene, typically responsible for the significant production of the more abundant PUFAs.[5]
In addition to their inflammatory nature, eicosanoids such as ETA can also contribute to an anti-inflammatory response.[5]
See also
References
- ^ Dennis EA, Norris PC (August 2015). "Eicosanoid storm in infection and inflammation". Nature Reviews. Immunology. 15 (8): 511–23. doi:10.1038/nri3859. PMC 4606863. PMID 26139350.
- ^ Lone AM, Taskén K (2013). "Proinflammatory and immunoregulatory roles of eicosanoids in T cells". Frontiers in Immunology. 4: 130. doi:10.3389/fimmu.2013.00130. PMC 3671288. PMID 23760108.
- ^ Deng H, Li W (April 2020). "Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders". Acta Pharmaceutica Sinica B. 10 (4): 582–602. doi:10.1016/j.apsb.2019.10.006. PMC 7161712. PMID 32322464.[permanent dead link]
- ^ Bierer TL, Bui LM (June 2002). "Improvement of arthritic signs in dogs fed green-lipped mussel (Perna canaliculus)". The Journal of Nutrition. 132 (6 Suppl 2): 1634S–6S. doi:10.1093/jn/132.6.1634S. PMID 12042477.
- ^ a b Okuda T, Ando A, Negoro H, Kikukawa H, Sakamoto T, Sakuradani E, Shimizu S, Ogawa J (September 2015). "Omega-3 eicosatetraenoic acid production by molecular breeding of the mutant strain S14 derived from Mortierella alpina 1S-4". Journal of Bioscience and Bioengineering. 120 (3): 299–304. doi:10.1016/j.jbiosc.2015.01.014. PMID 25845716.
This page was last edited on 14 May 2024, at 14:37