Dishevelled binding antagonist of beta catenin 2

DACT2

Identifiers

DACT2, C6orf116, DAPPER2, DPR2, bA503C24.7, dishevelled binding antagonist of beta catenin 2

External IDs

OMIM: 608966 MGI: 1920347 HomoloGene: 18237 GeneCards: DACT2

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6q27	Start	168,292,830 bp^[1]
Band	6q27	End	168,319,777 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17\|17 A2	Start	14,415,314 bp^[2]
Band	17\|17 A2	End	14,424,566 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

placenta

putamen

nucleus accumbens

caudate nucleus

minor salivary gland

skin of abdomen

right lobe of liver

prostate

body of pancreas

endometrium

Top expressed in

renal pelvis

midgut

umbilical vein

renal calyx

cervical loop

Hindgut

visual cortex

superior frontal gyrus

primary motor cortex

yolk sac

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein kinase C binding beta-catenin binding transcription factor binding protein kinase A binding delta-catenin binding
Cellular component	cytoplasm
Biological process	regulation of Wnt signaling pathway hematopoietic progenitor cell differentiation epithelial cell morphogenesis negative regulation of cell adhesion skin development inner medullary collecting duct development negative regulation of nodal signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


168002


240025

Ensembl


ENSG00000164488


ENSMUSG00000048826

UniProt


Q5SW24


Q7TN08

RefSeq (mRNA)


NM_001286350 NM_001286351 NM_214462


NM_172826

RefSeq (protein)


NP_001273279 NP_001273280 NP_999627


NP_766414

Location (UCSC)

Chr 6: 168.29 – 168.32 Mb

Chr 17: 14.42 – 14.42 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Dishevelled binding antagonist of beta catenin 2 is a protein that in humans is encoded by the DACT2 gene. ^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164488 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048826 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Dishevelled binding antagonist of beta catenin 2". Retrieved 2017-09-10.

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Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9): e12862. Bibcode:2010PLoSO...512862H. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.
Jia Y, Yang Y, Brock MV, Zhan Q, Herman JG, Guo M (2013). "Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer". J. Pathol. 230 (2): 194–204. doi:10.1002/path.4073. PMC 4061565. PMID 22806826.
Cheng H, Lu M, Mao LJ, Wang JQ, Li W, Wen RM, Chen JC (2012). "Relationships among MTHFR a1298c gene polymorphisms and methylation status of Dact1 gene in transitional cell carcinomas". Asian Pac. J. Cancer Prev. 13 (10): 5069–74. doi:10.7314/apjcp.2012.13.10.5069. PMID 23244112.
Zhang X, Yang Y, Liu X, Herman JG, Brock MV, Licchesi JD, Yue W, Pei X, Guo M (2013). "Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma". Epigenetics. 8 (4): 373–82. doi:10.4161/epi.24113. PMC 3674046. PMID 23449122.
Gao S, Yang Z, Zheng ZY, Yao J, Zhang F, Wu LM, Xie HY, Zhou L, Zheng SS (2013). "Reduced expression of DACT2 promotes hepatocellular carcinoma progression: involvement of methylation-mediated gene silencing". World J Surg Oncol. 11: 57. doi:10.1186/1477-7819-11-57. PMC 3605395. PMID 23496880.
Hou J, Liao LD, Xie YM, Zeng FM, Ji X, Chen B, Li LY, Zhu MX, Yang CX, Qing-Zhao, Chen T, Xu XE, Shen J, Guo MZ, Li EM, Xu LY (2013). "DACT2 is a candidate tumor suppressor and prognostic marker in esophageal squamous cell carcinoma". Cancer Prev Res (Phila). 6 (8): 791–800. doi:10.1158/1940-6207.CAPR-12-0352. PMID 23803417.
Wang S, Dong Y, Zhang Y, Wang X, Xu L, Yang S, Li X, Dong H, Xu L, Su L, Ng SS, Chang Z, Sung JJ, Zhang X, Yu J (2015). "DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon cancer". Oncogene. 34 (20): 2575–85. doi:10.1038/onc.2014.201. PMC 4761644. PMID 25023701.

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This page was last edited on 3 December 2023, at 22:18

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References

Further reading