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Delapril

From Wikipedia, the free encyclopedia

Delapril
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 2-[2,3-dihydro-1H-inden-2-yl-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]amino]acetic acid
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC26H32N2O5
Molar mass452.551 g·mol−1
3D model (JSmol)
  • O=C(OCC)[C@@H](N[C@H](C(=O)N(CC(=O)O)C2Cc1ccccc1C2)C)CCc3ccccc3
  • InChI=1S/C26H32N2O5/c1-3-33-26(32)23(14-13-19-9-5-4-6-10-19)27-18(2)25(31)28(17-24(29)30)22-15-20-11-7-8-12-21(20)16-22/h4-12,18,22-23,27H,3,13-17H2,1-2H3,(H,29,30)/t18-,23-/m0/s1 ☒N
  • Key:WOUOLAUOZXOLJQ-MBSDFSHPSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Delapril (INN, also known as alindapril) is an ACE inhibitor used as an antihypertensive drug[1] in some European and Asian countries but not in America.[2] It is taken orally, available in 15 mg and 30 mg tablets.[3]

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Transcription

Mechanism

Delapril is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion. The resulting vasodilation prevents the vasoconstrictive effects of angiotensin II. Angiotensin II-induced aldosterone secretion by the adrenal cortex is also decreased by Delapril, leading to increases in excretion of sodium and therefore increases water outflow.[4]

References

  1. ^ Otero ML (2007). "Manidipine-delapril combination in the management of hypertension". Vascular Health and Risk Management. 3 (3): 255–63. PMC 2293964. PMID 17703633.
  2. ^ "Delapril". Drugs.com.
  3. ^ "Delapril". cursoenarm.net. Retrieved 2016-08-28.
  4. ^ "Delapril". Pubchem. U.S. National Library of Medicine. Retrieved 2016-08-28.
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This page was last edited on 20 December 2023, at 20:11
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