Cyclin K

CCNK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I53, 4CXA, 4NST, 4UN0, 5EFQ, 5ACB
Identifiers
Aliases	CCNK, CPR4, Cyclin K, IDDHDF
External IDs	OMIM: 603544 MGI: 1276106 HomoloGene: 14748 GeneCards: CCNK
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.2 Start 99,481,169 bp[1] End 99,535,044 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 F1|12 59.23 cM Start 108,145,838 bp[2] End 108,169,618 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid monocyte tibialis anterior muscle parotid gland pancreatic ductal cell bone marrow cells secondary oocyte trachea rectum human penis Top expressed in interventricular septum seminiferous tubule spermatid spermatocyte yolk sac skeletal muscle tissue quadriceps femoris muscle gastrocnemius muscle visual cortex superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase binding RNA polymerase II CTD heptapeptide repeat kinase activity cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase regulator activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activator activity Cellular component cyclin K-CDK12 complex nucleus cyclin K-CDK13 complex nucleoplasm cyclin-dependent protein kinase holoenzyme complex cyclin/CDK positive transcription elongation factor complex Biological process positive regulation of cyclin-dependent protein serine/threonine kinase activity transcription elongation from RNA polymerase II promoter regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues regulation of transcription, DNA-templated cellular response to DNA damage stimulus transcription by RNA polymerase II negative regulation by host of viral genome replication positive regulation of transcription by RNA polymerase II cell division cell cycle protein phosphorylation transcription, DNA-templated snRNA transcription by RNA polymerase II positive regulation of phosphorylation of RNA polymerase II C-terminal domain regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription, elongation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8812 12454 Ensembl ENSG00000090061 ENSMUSG00000021258 UniProt O75909 O88874 Q3U3M5 RefSeq (mRNA) NM_001099402 NM_003858 NM_009832 RefSeq (protein) NP_001092872 NP_033962 Location (UCSC) Chr 14: 99.48 – 99.54 Mb Chr 12: 108.15 – 108.17 Mb PubMed search [3] [4]
Wikidata
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Cyclin-K is a protein that in humans is encoded by the CCNK gene.^[5][6][7]

Function

The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDKs) through conformational changes.^[8][9] Activation of CDKs through their cyclin partner, creates kinase complexes that will activate target proteins through phosphorylation. Targeted proteins can then ultimately regulate decisions of a cell's progression within the cell cycle to occur. This gene product may be seen to play a dual role in both regulating CDK and RNA polymerase II (RNAP2) activities.^[7] Cyclin K only uses RNA recruitment to activate transcription.^[10]

Interactions

Cyclin K has been shown to interact with multiple CDKs including CDK9 and latest CDK12 and CDK13.^[6][9] Roles include helping to phosphorylate C-terminal domains of subunits of RNAP2.^[11] Cyclin K is most noted for its associated induction of processive elongation.^[8] Also, identified with G1 and S phase cyclin activity, however functions are not deeply understood.^[5][12]

Cyclin K also interacts with HIV nef protein.^[13] In the presence of overexpressed Nef protein, Cyclin k and CDK9 binding is induced, inhibiting the positive elongation factor of other CDK9 binding complexes, resulting in an inhibition of specific HIV-1 gene expression.^[9][13] CDK 13 may also be characterized to interact with HIV mRNA splicing, alongside Nef, and the underexpression of Gag and Env related proteins.^[12][10]

Cyclin K is indispensable for Leukemia growth. SETD1A, is also known to bind Cyclin K through its FLOS domain.^[14] The interaction is shown to be important to DNA damage response genes and for Leukemia proliferation.^[10][14]

References

Further reading

External links

• Overview of all the structural information available in the PDB for UniProt: O75909 (Cyclin-K) at the PDBe-KB.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

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This page was last edited on 3 January 2024, at 23:25