| |
| Names | |
|---|---|
| IUPAC name
L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-prolyl-L-asparaginyl-L-glycyl-L-alanyl-L-α-glutamyl-L-α-aspartyl-L-α-glutamyl-L-seryl-L-alanyl-L-α-glutamyl-L-alanyl-L-phenylalanyl-L-prolyl-L-leucyl-L-α-glutamyl-L-phenylalanine
| |
| Identifiers | |
3D model (JSmol)
|
|
| ChemSpider | |
PubChem CID
|
|
| |
| |
| Properties | |
| C112H165N27O36 | |
| Molar mass | 2465.705 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |
Corticotropin-like intermediate [lobe] peptide (CLIP), also known as adrenocorticotropic hormone fragment 18-39 (ACTH(18-39)), is a naturally occurring, endogenous neuropeptide with a docosapeptide structure and the amino acid sequence Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP is generated as a proteolyic cleavage product of adrenocorticotropic hormone (ACTH),[1][2] which in turn is a cleavage product of proopiomelanocortin (POMC).[3] Its physiological role has been investigated in various tissues,[4][5] specifically in the central nervous system.[6][7][8][9][10]
It has been suggested to function as an insulin secretagogue in the pancreas.[11]
YouTube Encyclopedic
-
1/5Views:4 5226526 8661 19649 080
-
Melanocyte Stimulating Hormone: Anatomy and Physiology
-
𝐀𝐝𝐫𝐞𝐧𝐨𝐜𝐨𝐫𝐭𝐢𝐜𝐨𝐭𝐫𝐨𝐩𝐢𝐜 𝐇𝐨𝐫𝐦𝐨𝐧𝐞 | 𝐂𝐨𝐫𝐭𝐢𝐜𝐨𝐭𝐫𝐨𝐩𝐢𝐧 (𝐀𝐂𝐓𝐇)
-
Peptide v/s steroid hormones: A comparison #viveksirsphysiology #vsp
-
A&P II Unit 1-1
-
Posterior Pituitary Gland
Transcription
References
- ^ Gianoulakis C, Seidah NG, Routhier R, Chrétien M (December 1979). "Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia". The Journal of Biological Chemistry. 254 (23): 11903–6. doi:10.1016/S0021-9258(19)86402-5. PMID 227883.
- ^ Lloyd D. Fricker (24 July 1991). Peptide biosynthesis and processing. CRC Press. p. 78. ISBN 978-0-8493-8852-1. Retrieved 25 November 2011.
- ^ Anthony W. Norman; Gerald Litwack (26 September 1997). Hormones. Academic Press. pp. 12. ISBN 978-0-12-521441-4. Retrieved 25 November 2011.
- ^ Marshall JB, Kapcala LP, Manning LD, McCullough AJ (November 1984). "Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules". The Journal of Clinical Investigation. 74 (5): 1886–9. doi:10.1172/JCI111608. PMC 425369. PMID 6209301.
- ^ Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C (January 1991). "Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain". Brain Research Bulletin. 26 (1): 99–111. doi:10.1016/0361-9230(91)90194-O. PMID 1849784. S2CID 556547.
- ^ Shojiro Inoué; Shojiro Inoué (1989). Biology of sleep substances. CRC Press. p. 136. ISBN 978-0-8493-4822-8. Retrieved 25 November 2011.
- ^ Chastrette N, Cespuglio R, Jouvet M (February 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives". Neuropeptides. 15 (2): 61–74. doi:10.1016/0143-4179(90)90042-w. PMID 1981927. S2CID 41264103.
- ^ Chastrette N, Cespuglio R, Lin YL, Jouvet M (February 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes". Neuropeptides. 15 (2): 75–88. doi:10.1016/0143-4179(90)90043-x. PMID 1964203. S2CID 13731355.
- ^ Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP (March 2009). "Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain". Bulletin of Experimental Biology and Medicine. 147 (3): 319–22. doi:10.1007/s10517-009-0499-x. PMID 19529852. S2CID 29237407.
- ^ Seidenbecher T, Balschun D, Vogel D, Reymann KG (1993). "Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)]". Peptides. 14 (6): 1221–4. doi:10.1016/0196-9781(93)90179-K. PMID 8134304. S2CID 7935999.
- ^ Marshall, J. B.; Kapcala, L. P.; Manning, L. D.; McCullough, A. J. (November 1984). "Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules". The Journal of Clinical Investigation. 74 (5): 1886–1889. doi:10.1172/JCI111608. ISSN 0021-9738. PMC 425369. PMID 6209301.
External links
- Corticotropin-Like+Intermediate+Lobe+Peptide at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This page was last edited on 17 October 2022, at 15:12