The cords of Billroth (also known as splenic cords or red pulp cords) are found in the red pulp of the spleen between the sinusoids, consisting of fibrils and connective tissue cells with a large population of monocytes and macrophages. These cords contain half of the mouse body's monocytes as a reserve so that after tissue injury these monocytes can move in and aid locally sourced monocytes in wound healing.[1]
Erythrocytes pass through the cords of Billroth before entering the sinusoids. The passage into the sinusoids may be seen as a bottleneck, where erythrocytes need to be flexible in order to pass through. In disorders of erythrocyte shape and/or flexibility, such as hereditary spherocytosis, erythrocytes fail to pass through and get phagocytosed, causing extravascular hemolysis.[2]
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Spleen Anatomy and Physiology
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Medical School Histology Basics - Lymphoidal System
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Medical School Histology Basics - Connective Tissue
Transcription
Eponym
They are named for Theodor Billroth, Austrian surgeon.[3]
References
- ^ Swirski, FK; Nahrendorf, M; Etzrodt, M; Wildgruber, M; Cortez-Retamozo, V; Panizzi, P; Figueiredo, J-L; Kohler, RH; Chudnovskiy, A; Waterman, P; Aikawa, E; Mempel, TR; Libby, P; Weissleder, R; Pittet, MJ (2009). "Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites". Science. 325: 612–616. doi:10.1126/science.1175202. PMC 2803111. PMID 19644120.
- ^ Chapter 12, page 425 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.
- ^ synd/2727 at Who Named It?
External links
- Anatomy Atlases – Microscopic Anatomy, plate 09.175 - "Spleen: Red Pulp"
- Histology image: 07803loa – Histology Learning System at Boston University - "Lymphoid Tissues and Organs: splenic reticulum"
This page was last edited on 10 February 2024, at 20:31