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Clofibride

From Wikipedia, the free encyclopedia

Clofibride
Clinical data
ATC code
Pharmacokinetic data
MetabolismHydrolyzed to clofibric acid; hepatic glucuronidation
Elimination half-life12 hours (clofibric acid)
ExcretionRenal (mostly) and fecal
Identifiers
  • 3-(dimethylcarbamoyl)propyl 2-(4-chlorophenoxy)-2-methylpropanoate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.043.542 Edit this at Wikidata
Chemical and physical data
FormulaC16H22ClNO4
Molar mass327.81 g·mol−1
3D model (JSmol)
  • Clc1ccc(OC(C(=O)OCCCC(=O)N(C)C)(C)C)cc1
  • InChI=1S/C16H22ClNO4/c1-16(2,22-13-9-7-12(17)8-10-13)15(20)21-11-5-6-14(19)18(3)4/h7-10H,5-6,11H2,1-4H3 checkY
  • Key:CXQGFLBVUNUQIA-UHFFFAOYSA-N checkY
  (verify)

Clofibride is a fibrate. Clofibride is a derivative of clofibrate. In the body it is converted into 4-chlorophenoxyisobutyric acid (clofibric acid),[1] which is the true hypolipidemic agent.[2] So clofibride, just like clofibrate is a prodrug of clofibric acid.

References

  1. ^ "Clofibride".
  2. ^ Entry on Clofibrat. at: Römpp Online. Georg Thieme Verlag, retrieved 06. Mai 2020.


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This page was last edited on 23 January 2023, at 11:21
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