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Chebulagic acid

From Wikipedia, the free encyclopedia

Chebulagic acid
Identifiers
3D model (JSmol)
ChEMBL
UNII
  • InChI=1S/C41H30O27/c42-13-1-8(2-14(43)24(13)49)35(56)68-41-34-33-31(64-39(60)12(6-19(47)48)22-23-11(38(59)67-34)5-17(46)27(52)32(23)65-40(61)30(22)55)18(63-41)7-62-36(57)9-3-15(44)25(50)28(53)20(9)21-10(37(58)66-33) 4-16(45)26(51)29(21)54/h1-5,12,18,22,30-31,33-34,41-46,49-55H,6-7H2,(H,47,48)/t12-,18+,22-,30-,31+,33-,34+,41-/m0/s1
    Key: HGJXAVROWQLCTP-YABCKIEDSA-N
  • C1C2C3C(C(C(O2)OC(=O)C4=CC(=C(C(=C4)O)O)O)OC(=O)C5=CC(=C(C6=C5C(C(C(=O)O3)CC(=O)O)C(C(=O)O6)O)O)O)OC(=O)C7=CC(=C(C(=C7C8=C(C(=C(C=C8C(=O)O1)O)O)O)O)O)O
Properties
C41H30O27
Molar mass 954.66 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Chebulagic acid is a benzopyran tannin and an antioxidant that has many potential uses in medicine.

It has been found to be immunosuppressive,[1] hepatoprotective,[2] and a potent alpha-glucosidase inhibitor,[3][4] a human gut enzyme useful in diabetic studies.

It has been shown to be active against Staphylococcus aureus and Candida albicans.[5]

It is found in the plants Terminalia chebula, T. citrina and T. catappa.[6]

It is formed from geraniin through a glutathione-mediated conversion.[7]

YouTube Encyclopedic

  • 1/3
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  • Medicinal Tree Terminalia belerica/Belliric Myrobalan/Baehra/बहेड़ा
  • Medicinal importance of Haritaki/Chebulic Myrobalan/ریڑ;/harītakī (Terminalia chebula )
  • Medicinal importance of Haritaki/Chebulic Myrobalan/ریڑ;/harītakī (Terminalia chebula )

Transcription

References

  1. ^ HAMADA, Shin-ichi; KATAOKA, Takao; WOO, Je-Tae; YAMADA, Atsushi; YOSHIDA, Takashi; NISHIMURA, Toshio; OTAKE, Noboru; NAGAI, Kazuo (1997). "Immunosuppressive Effects of Gallic Acid and Chebulagic Acid on CTL-Mediated Cytotoxicity". Biological & Pharmaceutical Bulletin. 20 (9): 1017–1019. doi:10.1248/bpb.20.1017. PMID 9331989.
  2. ^ Kinoshita, S.; Inoue, Y.; Nakama, S.; Ichiba, T.; Aniya, Y. (November 2007). "Antioxidant and hepatoprotective actions of medicinal herb, Terminalia catappa L. from Okinawa Island and its tannin corilagin". Phytomedicine. 14 (11): 755–762. doi:10.1016/j.phymed.2006.12.012. PMID 17293097.
  3. ^ Sasidharan, I; Sundaresan, A; Nisha, VM; Kirishna, MS; Raghu, KG; Jayamurthy, P (2012). "Inhibitory effect of Terminalia chebula Retz. fruit extracts on digestive enzyme related to diabetes and oxidative stress". J Enzyme Inhib Med Chem. 27 (4): 578–86. doi:10.3109/14756366.2011.603130. PMID 22512724.
  4. ^ Pham, AT; Malterud, KE; Paulsen, BS; Diallo, D; Wangensteen, H (2014). "α-Glucosidase inhibition, 15-lipoxygenase inhibition, and brine shrimp toxicity of extracts and isolated compounds from Terminalia macroptera leaves". Pharm Biol. 52 (9): 1166–9. doi:10.3109/13880209.2014.880486. PMID 24635511. S2CID 10233899.
  5. ^ "Medicinal Plants of Myanmar". Archived from the original on 2008-12-06. Retrieved 2008-10-25.
  6. ^ Chemopreventive effect of punicalagin, a novel tannin component isolated from Terminalia catappa, on H-ras-transformed NIH3T3 cells. Pin-Shern Chen and Jih-Heng Li, Toxicology Letters, Volume 163, Issue 1, 5 May 2006, Pages 44-53
  7. ^ Glutathione-mediated conversion of the ellagitannin geraniin into chebulagic acid. Tanaka T, Kouno I and Nonaka G.I, Chemical and pharmaceutical bulletin, 1996, volume 44, no 1, pages 34-40, INIST 3003361


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This page was last edited on 23 August 2023, at 21:10
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