The calphostins are a class of closely related chemical compounds isolated from the fungus Cladosporium cladosporioides.[1][2] The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are inhibitors of protein kinase C (PKC). The most potent member of the series, calphostin C, has found use as a biochemical tool because of this activity.[3]
| ||
| Calpohostin | R1 | R2 |
| Calphostin A | Bz | Bz |
| Calphostin B | Bz | H |
| Calphostin C | Bz | 4-(HO)Bz |
| Calphostin D | H | H |
| Calphostin I | 4-(HO)Bz | 4-(HO)Bz |
Calphostin C
Calphostin C is a potent inhibitor of protein kinase C (PKC).
References
- ^ Kobayashi, E; Ando, K; Nakano, H; Iida, T; Ohno, H; Morimoto, M; Tamaoki, T (1989). "Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities". J. Antibiot. 42 (10): 1470–1474. doi:10.7164/antibiotics.42.1470. PMID 2478514.
- ^ Iida, T; Kobayashi, E; Yoshida, M; Sano, H (1989). "Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures". J. Antibiot. 42 (10): 1475–1481. doi:10.7164/antibiotics.42.1475. PMID 2478515.
- ^ Calphostin C (UCN-1028C)[permanent dead link] at Biomol
External links
Media related to Calphostins at Wikimedia Commons
This page was last edited on 7 January 2022, at 07:33