To install click the Add extension button. That's it.

The source code for the WIKI 2 extension is being checked by specialists of the Mozilla Foundation, Google, and Apple. You could also do it yourself at any point in time.

4,5
Kelly Slayton
Congratulations on this excellent venture… what a great idea!
Alexander Grigorievskiy
I use WIKI 2 every day and almost forgot how the original Wikipedia looks like.
Live Statistics
English Articles
Improved in 24 Hours
Added in 24 Hours
What we do. Every page goes through several hundred of perfecting techniques; in live mode. Quite the same Wikipedia. Just better.
.
Leo
Newton
Brights
Milds

From Wikipedia, the free encyclopedia

CRYGC
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCRYGC, CCL, CRYG3, CTRCT2, crystallin gamma C
External IDsOMIM: 123680 MGI: 88523 HomoloGene: 36281 GeneCards: CRYGC
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020989

NM_001082573
NM_007775

RefSeq (protein)

NP_066269

NP_001076042
NP_031801

Location (UCSC)Chr 2: 208.13 – 208.13 MbChr 1: 65.11 – 65.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Crystallin, gamma C, also known as CRYGC, is a protein which in humans is encoded by the CRYGC gene.[5][6]

YouTube Encyclopedic

  • 1/1
    Views:
    795
  • CONFERENCIA "Origen de los sistemas CRISPR y sus aplicaciones en biología" - Lluís Montoliu

Transcription

Function

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.[6]

Interactions

CRYGC has been shown to interact with CRYBB2,[7] CRYAA[7] and CRYAB.[7]

References

  1. ^ a b c ENSG00000285011 GRCh38: Ensembl release 89: ENSG00000163254, ENSG00000285011 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025952 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ den Dunnen JT, Moormann RJ, Cremers FP, Schoenmakers JG (1985). "Two human gamma-crystallin genes are linked and riddled with Alu-repeats". Gene. 38 (1–3): 197–204. doi:10.1016/0378-1119(85)90218-5. PMID 4065573.
  6. ^ a b "Entrez Gene: CRYGC crystallin, gamma C".
  7. ^ a b c Fu L, Liang JJ (February 2002). "Detection of protein-protein interactions among lens crystallins in a mammalian two-hybrid system assay". The Journal of Biological Chemistry. 277 (6): 4255–60. doi:10.1074/jbc.M110027200. PMID 11700327.

External links

Further reading


This page was last edited on 27 March 2024, at 16:00
Basis of this page is in Wikipedia. Text is available under the CC BY-SA 3.0 Unported License. Non-text media are available under their specified licenses. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc. WIKI 2 is an independent company and has no affiliation with Wikimedia Foundation.