CNTNAP4

CNTNAP4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NXQ
Identifiers
Aliases	CNTNAP4, CASPR4, contactin associated protein like 4, contactin associated protein family member 4
External IDs	OMIM: 610518; MGI: 2183572; HomoloGene: 24912; GeneCards: CNTNAP4; OMA:CNTNAP4 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q23.1 Start 76,277,278 bp[1] End 76,560,757 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 113,296,675 bp[2] End 113,609,349 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum endothelial cell inferior ganglion of vagus nerve pons substantia nigra subthalamic nucleus medulla oblongata hypothalamus cerebellar hemisphere Brodmann area 46 Top expressed in substantia nigra ventral tegmental area pontine nuclei dorsomedial hypothalamic nucleus cerebellar cortex habenula trigeminal ganglion retinal pigment epithelium dorsal tegmental nucleus lateral hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component integral component of membrane cell junction plasma membrane dendrite synapse presynaptic membrane membrane GABA-ergic synapse integral component of presynaptic membrane Biological process regulation of synaptic transmission, dopaminergic regulation of grooming behavior cell adhesion regulation of synaptic transmission, GABAergic regulation of synapse organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85445 170571 Ensembl ENSG00000152910 ENSMUSG00000031772 UniProt Q9C0A0 Q99P47 RefSeq (mRNA) NM_033401 NM_138994 NM_001322178 NM_001322179 NM_001322180 NM_001322181 NM_001322187 NM_001322188 NM_001322189 NM_001322190 NM_001322191 NM_130457 RefSeq (protein) NP_001309107 NP_001309108 NP_001309109 NP_001309110 NP_001309116 NP_001309117 NP_001309118 NP_001309119 NP_001309120 NP_207837 NP_620481 NP_569724 Location (UCSC) Chr 16: 76.28 – 76.56 Mb Chr 8: 113.3 – 113.61 Mb PubMed search [3] [4]
Wikidata
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Contactin-associated protein-like 4 is a protein that in humans is encoded by the CNTNAP4 gene.^[5][6]

This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. Alternative splicing results in two transcript variants encoding different isoforms.^[6]

References

External links

• Human CNTNAP4 genome location and CNTNAP4 gene details page in the UCSC Genome Browser.

Further reading

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

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This page was last edited on 28 October 2022, at 13:52