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Calcyphosin

From Wikipedia, the free encyclopedia

CAPS

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
3E3R

Identifiers

CAPS, CAPS1, calcyphosine

External IDs

OMIM: 114212 HomoloGene: 37871 GeneCards: CAPS

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.3	Start	5,912,339 bp^[1]
Band	19p13.3	End	5,916,211 bp^[1]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

bronchial epithelial cell

right uterine tube

trachea

pancreatic ductal cell

superior vestibular nucleus

tibial nerve

vena cava

seminal vesicula

left uterine tube

body of stomach

n/a

More reference expression data


More reference expression data

Gene ontology
Molecular function	metal ion binding calcium ion binding
Cellular component	vesicle extracellular exosome cytoplasm nucleus plasma membrane
Biological process	intracellular signal transduction
Sources:Amigo / QuickGO

Species

Human

Mouse


828


n/a


ENSG00000105519


n/a


Q13938


n/a

RefSeq (mRNA)


NM_004058 NM_080590


n/a

RefSeq (protein)


NP_004049 NP_542157


n/a

Location (UCSC)

Chr 19: 5.91 – 5.92 Mb

n/a

PubMed search

^[2]

n/a

View/Edit Human

Calcyphosin is a protein that in humans is encoded by the CAPS gene.^[3]^[4]^[5]

Function

This gene encodes a calcium-binding protein, which may play a role in the regulation of ion transport. A similar protein was first described as a potentially important regulatory protein in the dog thyroid and was termed as R2D5 antigen in rabbit. Alternative splicing of this gene generates two transcript variants.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105519 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ El Housni H, Radulescu A, Lecocq R, Dumont JE, Christophe D (Aug 1997). "Cloning and sequence analysis of human calcyphosine complementary DNA". Biochim Biophys Acta. 1352 (3): 249–52. doi:10.1016/s0167-4781(97)00073-0. PMID 9224948.
^ Lefort A, Passage E, Libert F, Szpirer J, Vassart G, Mattei MG (Feb 1991). "Localization of human calcyphosine gene (CAPS) to the p13.3 region of chromosome 19 by in situ hybridization". Cytogenet Cell Genet. 54 (3–4): 154–5. doi:10.1159/000132981. PMID 2265558.
^ ^a ^b "Entrez Gene: CAPS calcyphosine".

Further reading

Lefort A, Lecocq R, Libert F, et al. (1989). "Cloning and sequencing of a calcium-binding protein regulated by cyclic AMP in the thyroid". EMBO J. 8 (1): 111–6. doi:10.1002/j.1460-2075.1989.tb03354.x. PMC 400778. PMID 2540953.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Clément S, Dumont JE, Schurmans S (1997). "Loss of calcyphosine gene expression in mouse and other rodents". Biochem. Biophys. Res. Commun. 232 (2): 407–13. doi:10.1006/bbrc.1997.6297. PMID 9125191.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 29 September 2022, at 14:48

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