CADPS

CADPS

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1WI1

Identifiers

Aliases

CADPS, CADPS1, CAPS, CAPS1, UNC-31, Ca2+ dependent secretion activator, calcium dependent secretion activator

External IDs

OMIM: 604667 MGI: 1350922 HomoloGene: 2755 GeneCards: CADPS

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3p14.2	Start	62,398,346 bp^[1]
Band	3p14.2	End	62,875,416 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	14\|14 A1	Start	12,372,563 bp^[2]
Band	14\|14 A1	End	12,823,079 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

pons

Brodmann area 46

prefrontal cortex

Brodmann area 9

cerebellar cortex

cerebellar hemisphere

superior frontal gyrus

postcentral gyrus

islet of Langerhans

cingulate gyrus

Top expressed in

pontine nuclei

medial vestibular nucleus

dorsal tegmental nucleus

mammillary body

ventral tegmental area

dorsomedial hypothalamic nucleus

superior colliculus

medial geniculate nucleus

lateral geniculate nucleus

lateral hypothalamus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding protein kinase binding metal ion binding lipid binding
Cellular component	membrane cytoplasmic vesicle cytosol cell junction synapse cytoplasmic vesicle membrane presynapse glutamatergic synapse
Biological process	protein transport synaptic vesicle priming catecholamine secretion vesicle organization exocytosis synaptic vesicle exocytosis dense core granule exocytosis presynaptic dense core vesicle exocytosis positive regulation of exocytosis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8618


27062

Ensembl


ENSG00000163618


ENSMUSG00000054423

UniProt


Q9ULU8


Q80TJ1

RefSeq (mRNA)


NM_003716 NM_183393 NM_183394


NM_001042617 NM_012061 NM_001359919 NM_001359920 NM_001359921

RefSeq (protein)


NP_003707 NP_899630 NP_899631


NP_001036082 NP_036191 NP_001346848 NP_001346849 NP_001346850

Location (UCSC)

Chr 3: 62.4 – 62.88 Mb

Chr 14: 12.37 – 12.82 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Calcium-dependent secretion activator 1 is a protein that in humans is encoded by the CADPS gene.^[5]^[6]

CADPS encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. CADPS acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163618 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054423 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Walent JH, Porter BW, Martin TF (Oct 1992). "A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells". Cell. 70 (5): 765–75. doi:10.1016/0092-8674(92)90310-9. PMID 1516133. S2CID 29122392.
^ ^a ^b "Entrez Gene: CADPS Ca2+-dependent secretion activator".

External links

Human CADPS genome location and CADPS gene details page in the UCSC Genome Browser.
Human CAPS genome location and CAPS gene details page in the UCSC Genome Browser.

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nishizaki T, Walent JH, Kowalchyk JA, Martin TF (1992). "A key role for a 145-kDa cytosolic protein in the stimulation of Ca(2+)-dependent secretion by protein kinase C." J. Biol. Chem. 267 (33): 23972–81. doi:10.1016/S0021-9258(18)35932-5. PMID 1429734.
Ann K, Kowalchyk JA, Loyet KM, Martin TF (1997). "Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis". J. Biol. Chem. 272 (32): 19637–40. doi:10.1074/jbc.272.32.19637. PMID 9289490.
Loyet KM, Kowalchyk JA, Chaudhary A, et al. (1998). "Specific binding of phosphatidylinositol 4,5-bisphosphate to calcium-dependent activator protein for secretion (CAPS), a potential phosphoinositide effector protein for regulated exocytosis". J. Biol. Chem. 273 (14): 8337–43. doi:10.1074/jbc.273.14.8337. PMID 9525942.
Berwin B, Floor E, Martin TF (1998). "CAPS (mammalian UNC-31) protein localizes to membranes involved in dense-core vesicle exocytosis". Neuron. 21 (1): 137–45. doi:10.1016/S0896-6273(00)80521-8. PMID 9697858.
Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cisternas FA, Vincent JB, Scherer SW, Ray PN (2003). "Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family". Genomics. 81 (3): 279–91. doi:10.1016/S0888-7543(02)00040-X. PMID 12659812.
Speidel D, Varoqueaux F, Enk C, et al. (2004). "A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function". J. Biol. Chem. 278 (52): 52802–9. doi:10.1074/jbc.M304727200. PMID 14530279.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Binda AV, Kabbani N, Levenson R (2005). "Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS)". Biochem. Pharmacol. 69 (10): 1451–61. doi:10.1016/j.bcp.2005.02.015. PMID 15857609.

v t e PDB gallery
1wi1: Solution structure of the PH domain of human calcium-dependent activator protein for secretion (CAPS)

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This page was last edited on 3 March 2023, at 22:05

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References

External links

Further reading