Annexin A4

ANXA4

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2ZOC

Identifiers

Aliases

ANXA4, ANX4, HEL-S-274, PIG28, ZAP36, P32.5, PAP-II, PP4-X, annexin A4

External IDs

OMIM: 106491 MGI: 88030 HomoloGene: 68164 GeneCards: ANXA4

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2p13.3	Start	69,644,425 bp^[1]
Band	2p13.3	End	69,827,112 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6 D1\|6 37.75 cM	Start	86,713,822 bp^[2]
Band	6 D1\|6 37.75 cM	End	86,770,566 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

pancreatic ductal cell

gallbladder

jejunal mucosa

duodenum

body of pancreas

islet of Langerhans

bronchial epithelial cell

germinal epithelium

visceral pleura

Achilles tendon

Top expressed in

Paneth cell

jejunum

crypt of lieberkuhn of small intestine

gastric mucosa

epithelium of stomach

ileum

pyloric antrum

mucous cell of stomach

intestinal villus

duodenum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	phospholipase inhibitor activity calcium ion binding calcium-dependent protein binding NF-kappaB binding protein binding identical protein binding calcium-dependent phospholipid binding heparin binding chondroitin sulfate binding
Cellular component	cytoplasm nuclear membrane vesicle membrane plasma membrane cell surface perinuclear region of cytoplasm extracellular exosome nucleus cytosol collagen-containing extracellular matrix
Biological process	Notch signaling pathway epithelial cell differentiation regulation of transcription by RNA polymerase II negative regulation of apoptotic process negative regulation of NF-kappaB transcription factor activity signal transduction negative regulation of catalytic activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


307


11746

Ensembl


ENSG00000196975


ENSMUSG00000029994

UniProt


P09525


P97429

RefSeq (mRNA)


NM_001153 NM_001320698 NM_001320700 NM_001320702 NM_001365496


NM_013471 NM_001331120

RefSeq (protein)


NP_001144 NP_001307627 NP_001307629 NP_001307631 NP_001352425


NP_001318049 NP_038499

Location (UCSC)

Chr 2: 69.64 – 69.83 Mb

Chr 6: 86.71 – 86.77 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Annexin A4 is a protein that in humans is encoded by the ANXA4 gene.^[5]^[6]

Function

Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196975 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029994 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tait JF, Smith C, Frankenberry DA, Miao CH, Adler DA, Disteche CM (Feb 1992). "Chromosomal mapping of the human annexin IV (ANX4) gene". Genomics. 12 (2): 313–8. doi:10.1016/0888-7543(92)90379-7. PMID 1346776.
^ ^a ^b "Entrez Gene: ANXA4 annexin A4".

External links

Human ANXA4 genome location and ANXA4 gene details page in the UCSC Genome Browser.

Römisch J, Heimburger N (May 1990). "Purification and characterization of six annexins from human placenta". Biological Chemistry Hoppe-Seyler. 371 (5): 383–8. doi:10.1515/bchm3.1990.371.1.383. PMID 2143074.
Römisch J, Grote M, Weithmann KU, Heimburger N, Amann E (Nov 1990). "Annexin proteins PP4 and PP4-X. Comparative characterization of biological activities of placental and recombinant proteins". The Biochemical Journal. 272 (1): 223–9. doi:10.1042/bj2720223. PMC 1149680. PMID 2148260.
Freemont PS, Driessen HP, Verbi W, Crumpton MJ (Nov 1990). "Crystallization and preliminary X-ray crystallographic studies of human placental annexin IV". Journal of Molecular Biology. 216 (2): 219–21. doi:10.1016/S0022-2836(05)80310-9. PMID 2254922.
Hauptmann R, Maurer-Fogy I, Krystek E, Bodo G, Andree H, Reutelingsperger CP (Oct 1989). "Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha". European Journal of Biochemistry. 185 (1): 63–71. doi:10.1111/j.1432-1033.1989.tb15082.x. PMID 2530088.
Grundmann U, Amann E, Abel KJ, Küpper HA (Apr 1988). "Isolation and expression of cDNA coding for a new member of the phospholipase A2 inhibitor family". Behring Institute Mitteilungen (82): 59–67. PMID 2970257.
Ahn NG, Teller DC, Bienkowski MJ, McMullen BA, Lipkin EW, de Haën C (Dec 1988). "Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor". The Journal of Biological Chemistry. 263 (35): 18657–63. doi:10.1016/S0021-9258(18)37335-6. PMID 2974032.
Tait JF, Sakata M, McMullen BA, Miao CH, Funakoshi T, Hendrickson LE, Fujikawa K (Aug 1988). "Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family". Biochemistry. 27 (17): 6268–76. doi:10.1021/bi00417a011. PMID 2975506.
Sjölin C, Stendahl O, Dahlgren C (Jun 1994). "Calcium-induced translocation of annexins to subcellular organelles of human neutrophils". The Biochemical Journal. 300 ( Pt 2) (Pt 2): 325–30. doi:10.1042/bj3000325. PMC 1138165. PMID 8002935.
Kojima K, Yamamoto K, Irimura T, Osawa T, Ogawa H, Matsumoto I (Mar 1996). "Characterization of carbohydrate-binding protein p33/41: relation with annexin IV, molecular basis of the doublet forms (p33 and p41), and modulation of the carbohydrate binding activity by phospholipids". The Journal of Biological Chemistry. 271 (13): 7679–85. doi:10.1074/jbc.271.13.7679. PMID 8631806.
Davis AJ, Butt JT, Walker JH, Moss SE, Gawler DJ (Oct 1996). "The Ca2+-dependent lipid binding domain of P120GAP mediates protein-protein interactions with Ca2+-dependent membrane-binding proteins. Evidence for a direct interaction between annexin VI and P120GAP". The Journal of Biological Chemistry. 271 (40): 24333–6. doi:10.1074/jbc.271.40.24333. PMID 8798684.
Satoh A, Takayama E, Kojima K, Ogawa H, Yamori T, Sato S, Kawaguchi T, Tsuruo T, Katsura Y, Kina T, Matsumoto I (Feb 1996). "Expression of carbohydrate-binding protein p33/41 in human tumor cell lines". Journal of Biochemistry. 119 (2): 346–53. doi:10.1093/oxfordjournals.jbchem.a021246. PMID 8882729.
Satoh A, Takayama E, Kojima K, Ogawa H, Katsura Y, Kina T, Matsumoto I (Mar 1997). "Characterization of human p33/41 (annexin IV), a Ca2+ dependent carbohydrate-binding protein with monoclonal anti-annexin IV antibodies, AS11 and AS17". Biological & Pharmaceutical Bulletin. 20 (3): 224–9. doi:10.1248/bpb.20.224. PMID 9084877.
Dreier R, Schmid KW, Gerke V, Riehemann K (Aug 1998). "Differential expression of annexins I, II and IV in human tissues: an immunohistochemical study". Histochemistry and Cell Biology. 110 (2): 137–48. doi:10.1007/s004180050275. PMID 9720986. S2CID 19597353.
Chow A, Davis AJ, Gawler DJ (Mar 2000). "Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain". FEBS Letters. 469 (1): 88–92. doi:10.1016/S0014-5793(00)01252-7. PMID 10708762. S2CID 21394463.
Han EK, Tahir SK, Cherian SP, Collins N, Ng SC (Jul 2000). "Modulation of paclitaxel resistance by annexin IV in human cancer cell lines". British Journal of Cancer. 83 (1): 83–8. doi:10.1054/bjoc.2000.1311. PMC 2374538. PMID 10883672.
Radau B, Otto A, Müller EC, Westermann P (Jul 2000). "Protein kinase C alpha-dependent phosphorylation of Golgi proteins". Electrophoresis. 21 (13): 2684–7. doi:10.1002/1522-2683(20000701)21:13<2684::AID-ELPS2684>3.0.CO;2-G. PMID 10949146. S2CID 84800747.
Gerner C, Frohwein U, Gotzmann J, Bayer E, Gelbmann D, Bursch W, Schulte-Hermann R (Dec 2000). "The Fas-induced apoptosis analyzed by high throughput proteome analysis". The Journal of Biological Chemistry. 275 (50): 39018–26. doi:10.1074/jbc.M006495200. PMID 10978337.
Tsujii-Hayashi Y, Kitahara M, Yamagaki T, Kojima-Aikawa K, Matsumoto I (Dec 2002). "A potential endogenous ligand of annexin IV in the exocrine pancreas. Carbohydrate structure of GP-2, a glycosylphosphatidylinositol-anchored glycoprotein of zymogen granule membranes". The Journal of Biological Chemistry. 277 (49): 47493–9. doi:10.1074/jbc.M206572200. PMID 12324456.

v t e PDB gallery
1ann: ANNEXIN IV 1aow: ANNEXIN IV 1i4a: CRYSTAL STRUCTURE OF PHOSPHORYLATION-MIMICKING MUTANT T6D OF ANNEXIN IV

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Function

References

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Further reading