Annexin A13

ANXA13

Identifiers

ANXA13, ANX13, ISA, annexin A13

External IDs

OMIM: 602573 MGI: 1917037 HomoloGene: 20908 GeneCards: ANXA13

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	8q24.13	Start	123,680,794 bp^[1]
Band	8q24.13	End	123,737,402 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15 D1\|15 24.66 cM	Start	58,204,867 bp^[2]
Band	15 D1\|15 24.66 cM	End	58,261,093 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gallbladder

jejunal mucosa

duodenum

right uterine tube

rectum

pancreatic ductal cell

seminal vesicula

right lobe of liver

caput epididymis

kidney tubule

Top expressed in

duodenum

jejunum

ileum

pancreas

colon

islet of Langerhans

stomach

connecting tubule

midgut

proximal tubule

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	calcium-dependent phospholipid binding calcium ion binding phosphatidylserine binding phosphatidylcholine binding phosphatidylglycerol binding
Cellular component	membrane raft plasma membrane basolateral plasma membrane extracellular exosome apical plasma membrane exocytic vesicle membrane nucleoplasm extracellular space
Biological process	positive regulation of Golgi to plasma membrane protein transport cell differentiation negative regulation of Golgi to plasma membrane protein transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


312


69787

Ensembl


ENSG00000104537


ENSMUSG00000055114

UniProt


P27216


Q99JG3

RefSeq (mRNA)


NM_004306 NM_001003954


NM_027211

RefSeq (protein)


NP_001003954 NP_004297


NP_081487

Location (UCSC)

Chr 8: 123.68 – 123.74 Mb

Chr 15: 58.2 – 58.26 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Annexin A13 is a protein that in humans is encoded by the ANXA13 gene.^[5]^[6]

Function

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membranes of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104537 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055114 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Morgan RO, Bell DW, Testa JR, Fernandez MP (Feb 1998). "Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins". Genomics. 48 (1): 100–10. doi:10.1006/geno.1997.5148. PMID 9503022.
^ ^a ^b "Entrez Gene: ANXA13 annexin A13".

External links

Human ANXA13 genome location and ANXA13 gene details page in the UCSC Genome Browser.

Wice BM, Gordon JI (Jan 1992). "A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin". The Journal of Cell Biology. 116 (2): 405–22. doi:10.1083/jcb.116.2.405. PMC 2289284. PMID 1530946.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Plant PJ, Lafont F, Lecat S, Verkade P, Simons K, Rotin D (Jun 2000). "Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb". The Journal of Cell Biology. 149 (7): 1473–84. doi:10.1083/jcb.149.7.1473. PMC 2175132. PMID 10871286.
Noda Y, Okada Y, Saito N, Setou M, Xu Y, Zhang Z, Hirokawa N (Oct 2001). "KIFC3, a microtubule minus end-directed motor for the apical transport of annexin XIIIb-associated Triton-insoluble membranes". The Journal of Cell Biology. 155 (1): 77–88. doi:10.1083/jcb.200108042. PMC 2150803. PMID 11581287.
Iglesias JM, Morgan RO, Jenkins NA, Copeland NG, Gilbert DJ, Fernandez MP (May 2002). "Comparative genetics and evolution of annexin A13 as the founder gene of vertebrate annexins". Molecular Biology and Evolution. 19 (5): 608–18. doi:10.1093/oxfordjournals.molbev.a004120. PMID 11961095.
Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A (Apr 2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Molecular & Cellular Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.

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This page was last edited on 4 March 2023, at 00:10

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Function

References

External links

Further reading