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Almoxatone

From Wikipedia, the free encyclopedia

Almoxatone
Clinical data
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • (5R)-3-{4-[(3-chlorobenzyl)oxy]phenyl}-5-[(methylamino)methyl]-1,3-oxazolidin-2-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H19ClN2O3
Molar mass346.81 g·mol−1
3D model (JSmol)
  • Clc1cccc(c1)COc3ccc(N2C(=O)O[C@H](CNC)C2)cc3
  • InChI=1S/C18H19ClN2O3/c1-20-10-17-11-21(18(22)24-17)15-5-7-16(8-6-15)23-12-13-3-2-4-14(19)9-13/h2-9,17,20H,10-12H2,1H3/t17-/m1/s1 checkY
  • Key:KYXSTSXVEXKFJI-QGZVFWFLSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Almoxatone (MD-780,236) is a selective and reversible inhibitor of MAO-B.[1][2] It was patented as an antidepressant and antiparkinsonian agent but was never marketed.[3]

See also

References

  1. ^ Tipton KF, Fowler CJ, McCrodden JM, Strolin Benedetti M (January 1983). "The enzyme-activated irreversible inhibition of type-B monoamine oxidase by 3-(4-[(3-chlorophenyl)methoxy]phenyl)-5-[(methylamino) methyl]-2-oxazolidinone methanesulphonate (compound MD 780236) and the enzyme-catalysed oxidation of this compound as competing reactions". The Biochemical Journal. 209 (1): 235–42. doi:10.1042/bj2090235. PMC 1154077. PMID 6847610.
  2. ^ Dostert P, Strolin Benedetti M, Guffroy C (March 1983). "Different stereoselective inhibition of monoamine oxidase-B by the R- and S-enantiomers of MD 780236". The Journal of Pharmacy and Pharmacology. 35 (3): 161–5. doi:10.1111/j.2042-7158.1983.tb04297.x. PMID 6132973. S2CID 10074323.
  3. ^ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.


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This page was last edited on 15 December 2022, at 06:45
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