AHSA1

AHSA1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1X53

Identifiers

Aliases

AHSA1, AHA1, C14orf3, p38, hAha1, activator of Hsp90 ATPase activity 1

External IDs

OMIM: 608466 MGI: 2387603 HomoloGene: 8106 GeneCards: AHSA1

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q24.3	Start	77,457,870 bp^[1]
Band	14q24.3	End	77,469,472 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 D2	Start	87,313,253 bp^[2]
Band	12\|12 D2	End	87,320,772 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

oocyte

secondary oocyte

right uterine tube

ganglionic eminence

Brodmann area 9

prefrontal cortex

right adrenal gland

left adrenal gland

rectum

cerebellar hemisphere

Top expressed in

saccule

otic placode

maxillary prominence

somite

yolk sac

facial motor nucleus

primitive streak

lens

knee joint

cerebellar cortex

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	ATPase activator activity chaperone binding protein binding cadherin binding Hsp90 protein binding
Cellular component	extracellular exosome endoplasmic reticulum cytoplasm cytosol
Biological process	response to stress positive regulation of ATP-dependent activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10598


217737

Ensembl


ENSG00000100591


ENSMUSG00000021037

UniProt


O95433


Q8BK64

RefSeq (mRNA)


NM_012111 NM_001321441


NM_146036

RefSeq (protein)


NP_001308370 NP_036243


NP_666148

Location (UCSC)

Chr 14: 77.46 – 77.47 Mb

Chr 12: 87.31 – 87.32 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Activator of 90 kDa heat shock protein ATPase homolog 1 is an enzyme that in humans is encoded by the AHSA1 gene.^[5]

YouTube Encyclopedic

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Transcription

Interactions

AHSA1 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100591 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021037 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)".
^ Panaretou B, Siligardi G, Meyer P, Maloney A, Sullivan JK, Singh S, Millson SH, Clarke PA, Naaby-Hansen S, Stein R, Cramer R, Mollapour M, Workman P, Piper PW, Pearl LH, Prodromou C (Dec 2002). "Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1" (PDF). Mol. Cell. 10 (6): 1307–18. doi:10.1016/S1097-2765(02)00785-2. PMID 12504007.

External links

Human AHSA1 genome location and AHSA1 gene details page in the UCSC Genome Browser.

Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Sevier CS, Machamer CE (2001). "p38: A novel protein that associates with the vesicular stomatitis virus glycoprotein". Biochem. Biophys. Res. Commun. 287 (2): 574–82. doi:10.1006/bbrc.2001.5621. PMID 11554768.
Panaretou B, Siligardi G, Meyer P, Maloney A, Sullivan JK, Singh S, Millson SH, Clarke PA, Naaby-Hansen S, Stein R, Cramer R, Mollapour M, Workman P, Piper PW, Pearl LH, Prodromou C (2002). "Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1" (PDF). Mol. Cell. 10 (6): 1307–18. doi:10.1016/S1097-2765(02)00785-2. PMID 12504007.
Lotz GP, Lin H, Harst A, Obermann WM (2003). "Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone". J. Biol. Chem. 278 (19): 17228–35. doi:10.1074/jbc.M212761200. PMID 12604615.
Swick L, Kapatos G (2006). "A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions". J. Neurochem. 97 (5): 1447–55. doi:10.1111/j.1471-4159.2006.03836.x. PMC 2239266. PMID 16696853.
Wang X, Venable J, LaPointe P, Hutt DM, Koulov AV, Coppinger J, Gurkan C, Kellner W, Matteson J, Plutner H, Riordan JR, Kelly JW, Yates JR, Balch WE (2006). "Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis". Cell. 127 (4): 803–15. doi:10.1016/j.cell.2006.09.043. PMID 17110338. S2CID 1457851.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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1x53: The solution structure of the C-terminal domain of human Activator of 90 kDa heat shock protein ATPase homolog 1

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 17 October 2022, at 02:41

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Transcription

Interactions

References

External links

Further reading