Renin receptor

ATP6AP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LBS, 3LC8
Identifiers
Aliases	ATP6AP2, APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS, HT028, ATPase H+ transporting accessory protein 2, CDG2R
External IDs	OMIM: 300556 MGI: 1917745 HomoloGene: 38097 GeneCards: ATP6AP2
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.4 Start 40,579,372 bp[1] End 40,606,848 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A1.1 Start 12,454,040 bp[2] End 12,483,288 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in visceral pleura tibia germinal epithelium parietal pleura retinal pigment epithelium orbitofrontal cortex renal medulla pons Brodmann area 23 bronchial epithelial cell Top expressed in Paneth cell ciliary body iris retinal pigment epithelium conjunctival fornix substantia nigra medial dorsal nucleus medial geniculate nucleus aortic valve barrel cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding enzyme binding signaling receptor activity Cellular component integral component of membrane plasma membrane extracellular exosome membrane external side of plasma membrane neuron projection cell body tertiary granule membrane ficolin-1-rich granule membrane extracellular space apical plasma membrane Biological process positive regulation of transforming growth factor beta1 production rostrocaudal neural tube patterning head morphogenesis regulation of MAPK cascade eye pigmentation angiotensin maturation positive regulation of Wnt signaling pathway neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10159 70495 Ensembl ENSG00000182220 ENSMUSG00000031007 UniProt O75787 Q9CYN9 RefSeq (mRNA) NM_005765 NM_027439 RefSeq (protein) NP_005756 NP_081715 Location (UCSC) Chr X: 40.58 – 40.61 Mb Chr X: 12.45 – 12.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2, or the prorenin receptor, is a protein that in humans is encoded by the ATP6AP2 gene.^[5][6][7]

Function

The renin receptor binds renin and prorenin. Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I.^[8]

This protein is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.^[7]

References

Further reading

External links

• ATP6AP2 human gene location in the UCSC Genome Browser.
• ATP6AP2 human gene details in the UCSC Genome Browser.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

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This page was last edited on 11 January 2024, at 06:45