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Kelly Slayton
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Alexander Grigorievskiy
I use WIKI 2 every day and almost forgot how the original Wikipedia looks like.
N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3gene.[5][6]
The protein encoded by this gene interacts with the amino-terminal domain of the amyloid beta A4 precursor protein-binding family A member 2 (APBA2), inhibits the association of APBA2 with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by APBA2. This protein, together with APBA2, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.[6]
Sugita S, Südhof TC (2000). "Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins". Biochemistry. 39 (11): 2940–9. doi:10.1021/bi9920984. PMID10715114.
Sugita S, Ho A, Südhof TC (2002). "NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern". Neuroscience. 112 (1): 51–63. doi:10.1016/S0306-4522(02)00063-5. PMID12044471. S2CID18740496.
Yoo JC, Chang JR, Kim SH, et al. (2004). "NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi". Exp. Cell Res. 292 (2): 393–402. doi:10.1016/j.yexcr.2003.09.025. PMID14697346.