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AM-0902

From Wikipedia, the free encyclopedia

AM-0902
Identifiers
  • 1-({3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl}methyl)-7-methylpurin-6-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC17H15ClN6O2
Molar mass370.80 g·mol−1
3D model (JSmol)
  • CN1C=NC2=C1C(=O)N(C=N2)CC3=NC(=NO3)CCC4=CC=C(C=C4)Cl
  • InChI=1S/C17H15ClN6O2/c1-23-9-19-16-15(23)17(25)24(10-20-16)8-14-21-13(22-26-14)7-4-11-2-5-12(18)6-3-11/h2-3,5-6,9-10H,4,7-8H2,1H3
  • Key:AWJBWNUUODWOKQ-UHFFFAOYSA-N

AM-0902 is a drug which acts as a potent and selective antagonist for the TRPA1 receptor, and has analgesic and antiinflammatory effects.[1][2]

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Transcription

References

  1. ^ Schenkel LB, Olivieri PR, Boezio AA, Deak HL, Emkey R, Graceffa RF, et al. (March 2016). "Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity". Journal of Medicinal Chemistry. 59 (6): 2794–809. doi:10.1021/acs.jmedchem.6b00039. PMID 26942860.
  2. ^ Huang Y, Chen SR, Chen H, Pan HL (May 2019). "Endogenous transient receptor potential ankyrin 1 and vanilloid 1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain". Journal of Neurochemistry. 149 (3): 381–398. doi:10.1111/jnc.14677. PMC 6483867. PMID 30716174.


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This page was last edited on 27 January 2023, at 15:41
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