| |
| Names | |
|---|---|
| Preferred IUPAC name
3,3′-Methylenedi(1H-indole) | |
| Other names
3-(1H-Indol-3-ylmethyl)-1H-indole
3,3′-Methylenebis-1H-indole DIM | |
| Identifiers | |
3D model (JSmol)
|
|
| 223072 | |
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| DrugBank | |
| ECHA InfoCard | 100.124.716 |
| EC Number |
|
PubChem CID
|
|
| UNII | |
CompTox Dashboard (EPA)
|
|
| |
| |
| Properties | |
| C17H14N2 | |
| Molar mass | 246.313 g·mol−1 |
| Hazards | |
| GHS labelling: | |
| |
| Warning | |
| H315, H319, H335, H413 | |
| P261, P264, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |
3,3′-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in cruciferous vegetables, such as broccoli, Brussels sprouts, cabbage and kale.[1] It and its parent compound – indole-3-carbinol – are under laboratory research to determine their possible biological properties, particularly in anti-cancer mechanisms.[1][2][3] DIM is sold as a dietary supplement.[1]
YouTube Encyclopedic
-
1/5Views:40 2451 5051 9812 560692
-
DIM - Control & Reverse Estrogen Dominance & Balance in Women & Men - PCOS - Diindolylmethane
-
DIM - The Potent Detoxifier (Diindolylmethane) - Your Health with Dr. Richard and Cindy Becker
-
Herbs And Supplements That Help Shrink Fibroids | Fibroids treatment
-
Supplements to take with testosterone injections and TRT treatment- testosterone supplements
-
Your Health Questions (Show #1595)
Transcription
Properties
In vitro, DIM has action as a histone deacetylase inhibitor,[1] specifically against HDAC1, HDAC2, and HDAC3.[4] DIM is a metabolite of indole-3-carbinol.[1][2][3] DIM was found to be a mild cannabinoid agonist with low binding affinity for both CB1 and CB2.[5][6]
Researchers from Ben-Gurion University of the Negev, in collaboration with teams from Sichuan University and the National University of Singapore, have identified that 3,3′-Diindolylmethane (DIM) – a naturally occurring molecule also referred to as bisindole – can reduce biofilms responsible for plaque and cavities by a remarkable 90%. [7]
See also
- Glucobrassicin, precursor to indole-3-carbinol
- Phytochemicals
References
- ^ a b c d e "Indole-3-carbinol". Micronutrient Information Center, Linus Pauling Institute, Oregon State University. 1 July 2017. Retrieved 11 July 2022.
- ^ a b "Indole-3-Carbinol". Memorial Sloan Kettering Cancer Center. Retrieved 2019-09-03.
- ^ a b "3,3'-Diindolylmethane". PubChem, US National Library of Medicine. 9 July 2022. Retrieved 11 July 2022.
- ^ Rajendran, P; Ho, E; Williams, DE; Dashwood, RH (2011). "Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells". Clinical Epigenetics. 3 (1): 4. doi:10.1186/1868-7083-3-4. PMC 3255482. PMID 22247744.
- ^ Andhika B. Mahardhika; et al. (March 2023). "Design, synthesis, and structure–activity relationships of diindolylmethane derivatives as cannabinoid CB2 receptor agonists". Archiv der Pharmazie. 356 (3): e2200493. doi:10.1002/ardp.202200493. PMID 36437108.
- ^ Paolo Tucci; et al. (2023). "The Plant Derived 3-3′-Diindolylmethane (DIM) Behaves as CB2 Receptor Agonist in Prostate Cancer Cellular Models". International Journal of Molecular Sciences. 24 (4): 3620. doi:10.3390/ijms24043620. hdl:2164/20232. PMC 9962283. PMID 36835033.
- ^ Yifat Baruch; et al. (6 June 2023). "3,3′-Diindolylmethane (DIM): A Potential Therapeutic Agent against Cariogenic Streptococcus mutans Biofilm". Antibiotics. 12 (6): 1017. doi:10.3390/antibiotics12061017. PMC 10295630. PMID 37370336.
External links
- Diindolylmethane Information Resource Center, University of California-Berkeley
This page was last edited on 30 October 2023, at 03:34