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Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the SULT2A1gene.[5][6][7]
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Transcription
Function
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene is primarily expressed in liver and adrenal tissues where the encoded protein sulfonates steroids and bile acids.[5]
Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett. 112–113: 341–8. doi:10.1016/S0378-4274(99)00214-3. PMID10720750.
Kong AN, Yang L, Ma M, et al. (1992). "Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver". Biochem. Biophys. Res. Commun. 187 (1): 448–54. doi:10.1016/S0006-291X(05)81514-1. PMID1520333.
Comer KA, Falany CN (1992). "Immunological characterization of dehydroepiandrosterone sulfotransferase from human liver and adrenal". Mol. Pharmacol. 41 (4): 645–51. PMID1569919.
Otterness DM, Wieben ED, Wood TC, et al. (1992). "Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA". Mol. Pharmacol. 41 (5): 865–72. PMID1588921.
Forbes KJ, Hagen M, Glatt H, et al. (1995). "Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme". Mol. Cell. Endocrinol. 112 (1): 53–60. doi:10.1016/0303-7207(95)03585-U. PMID7589785. S2CID39327051.
Luu-The V, Dufort I, Paquet N, et al. (1995). "Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene". DNA Cell Biol. 14 (6): 511–8. doi:10.1089/dna.1995.14.511. PMID7598806.
Falany CN, Wheeler J, Oh TS, Falany JL (1994). "Steroid sulfation by expressed human cytosolic sulfotransferases". J. Steroid Biochem. Mol. Biol. 48 (4): 369–75. doi:10.1016/0960-0760(94)90077-9. PMID8142314. S2CID37646598.
Barker EV, Hume R, Hallas A, Coughtrie WH (1994). "Dehydroepiandrosterone sulfotransferase in the developing human fetus: quantitative biochemical and immunological characterization of the hepatic, renal, and adrenal enzymes". Endocrinology. 134 (2): 982–9. doi:10.1210/endo.134.2.8299591. PMID8299591.
Durocher F, Morissette J, Dufort I, et al. (1996). "Genetic linkage mapping of the dehydroepiandrosterone sulfotransferase (STD) gene on the chromosome 19q13.3 region". Genomics. 29 (3): 781–3. doi:10.1006/geno.1995.9935. PMID8575776.
Tashiro A, Sasano H, Nishikawa T, et al. (2000). "Expression and activity of dehydroepiandrosterone sulfotransferase in human gastric mucosa". J. Steroid Biochem. Mol. Biol. 72 (3–4): 149–54. doi:10.1016/S0960-0760(00)00020-0. PMID10775806. S2CID44681209.
This page was last edited on 19 March 2024, at 03:54