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Phenprobamate

From Wikipedia, the free encyclopedia

Phenprobamate
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Legal status
Legal status
Pharmacokinetic data
Elimination half-life5–8 hours
Identifiers
  • 3-Phenylpropylcarbamate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.010.552 Edit this at Wikidata
Chemical and physical data
FormulaC10H13NO2
Molar mass179.219 g·mol−1
3D model (JSmol)
  • O=C(OCCCc1ccccc1)N
  • InChI=1S/C10H13NO2/c11-10(12)13-8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H2,11,12) checkY
  • Key:CAMYKONBWHRPDD-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Phenprobamate (Gamaquil, Isotonil, Actozine) is a centrally acting skeletal muscle relaxant, with additional sedative and anticonvulsant effects.[2][unreliable source?] Overdose is similar to barbiturates. Its mechanism of action is probably similar to meprobamate. Phenprobamate has been used in humans as an anxiolytic, and is still sometimes used in general anesthesia and for treating muscle cramps and spasticity. Phenprobamate is still used in some European countries, but it has generally been replaced by newer drugs. Phenprobamate is metabolized by oxidative degradation of the carbamate group and ortho-hydroxylation of the benzene ring, and is eliminated in urine by the kidneys.[citation needed]

Doses range from 400 to 800 mg, up to 3 times a day.[3]

References

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ Demir B, Demir Y, Aksoy I, Kilic OH, Gucyetmez V, Savas HA (June 2015). "Phenprobamate dependence: a case report". Addictive Behaviors. 45: 232–3. doi:10.1016/j.addbeh.2015.01.037. PMID 25727392.
  3. ^ "(meprobamate) dosing, indications, interactions, adverse effects, and more". Medscape. WebMD LLC. Retrieved 21 March 2024.

Further reading

External links


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This page was last edited on 23 March 2024, at 09:30
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