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Protein boule-like is a protein that in humans is encoded by the BOLLgene.[5][6][7]
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Transcription
Function
This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meioticG2 / M transition in fruitfly but in mice the primary defect is postmeiotic at round spermatid stage.[8] Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[7][9]
The boule-like protein appears to be ubiquitously expressed in males of all animal species, except in the most primitive trichoplax.[10]