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Aglepristone

From Wikipedia, the free encyclopedia

Aglepristone
Clinical data
Trade namesAlizin
Other namesRU-46534; RU-534; 11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17α-[(Z)-propenyl]estra-4,9-dien-3-one
Drug classAntiprogestogen; Antiglucocorticoid
ATC code
Identifiers
  • (8S,11R,13S,14S,17R)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.211.372 Edit this at Wikidata
Chemical and physical data
FormulaC29H37NO2
Molar mass431.620 g·mol−1
3D model (JSmol)
  • C/C=C\[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O
  • InChI=1S/C29H37NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h5-7,9-10,15,17,24-26,32H,8,11-14,16,18H2,1-4H3/b15-5-/t24-,25+,26-,28-,29-/m0/s1
  • Key:RTCKAOKDXNYXEH-FWSJOHTJSA-N

Aglepristone (INNTooltip International Nonproprietary Name) (brand name Alizin; former developmental code names RU-46534, RU-534) is a synthetic, steroidal antiprogestogen related to mifepristone which is marketed by Virbac in several European countries for use in veterinary medicine.[1][2][3] It is specifically used as an abortifacient in pregnant animals.[1][3][4] Aglepristone, similarly to mifepristone, also possesses some antiglucocorticoid activity.[5][6]

See also

References

  1. ^ a b Kaufman LK, Baldwin CJ (1 December 2013). "Pregnancy Loss in the Bitch and Queen". In Bonagura JD, Twedt DC (eds.). Kirk's Current Veterinary Therapy XV. Elsevier Health Sciences. pp. 3009–. ISBN 978-0-323-22762-9.
  2. ^ Squires EJ (2010). "Endocrine manipulation of reproduction.". Applied Animal Endocrinology. CABI. pp. 207–. ISBN 978-1-84593-755-3.
  3. ^ a b Papich MC (3 November 2010). "Aglepristone". Saunders Handbook of Veterinary Drugs: Small and Large Animal. Elsevier Health Sciences. pp. 120–. ISBN 978-1-4377-0192-0.
  4. ^ Fieni F, Martal J, Marnet PG, Siliart B, Bernard F, Riou M, Bruyas JF, Tainturier D (2001). Concannon PW (ed.). "Hormonal variation in bitches after early or mid-pregnancy termination with aglepristone (RU534)". Journal of Reproduction and Fertility. Supplement. Advances in reproduction in dogs, cats and exotic carnivores: proceedings of the fourth International Symposium on Canine and Feline Reproduction, Oslo, Norway, 29 June-1 July 2000. 57: 243–8. ISBN 978-0-906545-37-9. PMID 11787157.
  5. ^ Batista M, Reyes R, Santana M, Alamo D, Vilar J, González F, et al. (October 2011). "Induction of parturition with aglepristone in the Majorera goat". Reproduction in Domestic Animals = Zuchthygiene. 46 (5): 882–888. doi:10.1111/j.1439-0531.2011.01759.x. PMID 21320179.
  6. ^ Baan M, Taverne MA, de Gier J, Kooistra HS, Kindahl H, Dieleman SJ, Okkens AC (March 2008). "Hormonal changes in spontaneous and aglépristone-induced parturition in dogs". Theriogenology. 69 (4): 399–407. doi:10.1016/j.theriogenology.2007.10.008. PMID 18054071.
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This page was last edited on 28 May 2024, at 16:13
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